“Amyloid-beta accumulation in the brain is proposed to be an early event in the pathogenesis of Alzheimer’s disease, the most common type of dementia worldwide, impacting millions of people.” “Amyloid-beta is a molecule not normally found in the brains of young patients,” said study author Carlos Leiva-Salinas, MD, PhD, MBA, associate professor of radiology at the University of Missouri School of Medicine in Columbia. Certain forms of amyloid-beta can accumulate into tangles and plaques in the brain which can lead to cognitive decline and neurodegenerative diseases such as AD. Research over the last several decades suggests that there might be a relationship between repetitive or severe traumatic brain injury (TBI) and abnormal amyloid-beta accumulation. The results of the study were published today in Radiology. New research finds that the brains of otherwise healthy military personnel who are exposed to explosions show an abnormal brain accumulation of amyloid-beta protein-a protein that plays a role in the development of Alzheimer’s disease (AD).

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